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Arch Virol. 2012 Dec;157(12):2405-9. doi: 10.1007/s00705-012-1426-4. Epub 2012 Aug 11.

Rotavirus infection in children of Nizhny Novgorod, Russia: the gradual change of the virus allele from P[8]-1 to P[8]-3 in the period 1984-2010.

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Laboratory of Molecular Epidemiology of Viral Infections, IN Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia.


A collection of rotavirus samples collected over a 26-year period was examined to study the dynamics of change in RV strains of genotype P[8] in a geographically defined population (Nizhny Novgorod, Russia; children under 6 years) with no vaccine pressure. Phylogenetic analysis of gene VP4 (subunit VP8*) showed the presence of two lines of genotype P[8]: P[8]-1 and P[8]-3. Since 1997, the dominant population of rotavirus has been occupied by strains carrying the allele P[8]-3, which is associated with G1, G3 and G4. The complete replacement of the allele P[8]-1 to P[8]-3 took 19 epidemic years.

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