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Transcription. 2012 Sep-Oct;3(5):240-4. doi: 10.4161/trns.21297. Epub 2012 Sep 1.

How p53 wields the scales of fate: arrest or death?

Author information

1
p53 Laboratory, Agency for Science, Technology and Research, Singapore.

Abstract

Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformation is key to target gene selection.

KEYWORDS:

p53; protein conformation; reporter mouse models; target gene selection; tumor suppression

PMID:
22885979
PMCID:
PMC3632620
DOI:
10.4161/trns.21297
[Indexed for MEDLINE]
Free PMC Article
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