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Nat Neurosci. 2012 Sep;15(9):1192-4. doi: 10.1038/nn.3190. Epub 2012 Aug 12.

Experience-dependent regulation of NG2 progenitors in the developing barrel cortex.

Author information

1
Center for Neuroscience Research, Children's National Medical Center, Washington, DC, USA. jean-marie.mangin@inserm.fr

Abstract

We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.

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PMID:
22885848
PMCID:
PMC3437334
DOI:
10.1038/nn.3190
[Indexed for MEDLINE]
Free PMC Article

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