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Blood Coagul Fibrinolysis. 2012 Oct;23(7):649-52.

Effects of prothrombotic markers and non-O blood group in maternal venous thromboembolism during pregnancy and postpartum.

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Unit of Molecular Biology, Department of Hematology, Military Hospital, Tunis, Tunisia.


Our aim was to assess thrombophilic risk factors and the non-O blood group as contributors to the development of venous thromboembolism during pregnancy and the postpartum period. A total of 199 women underwent blood typing and an extensive thombophilia screening. Factor V Leiden, FII G20210A, protein C deficiency and non-O blood group were significantly associated with venous thromboembolism during pregnancy and postpartum period. A known thrombophilic factor may have consequences for future pregnancies and could have implications for clinical practice. For this reason, women with a history of thromboembolism should be screened for thrombophilia. The non-O blood group could also have an important influence, especially when concomitant with another prothrombotic risk factor mainly pregnancy and thrombophilia.

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