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Autophagy. 2012 Sep;8(9):1392-3. doi: 10.4161/auto.21035. Epub 2012 Aug 13.

UVRAG: at the crossroad of autophagy and genomic stability.

Author information

1
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.

Abstract

UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent of its role in autophagy signaling. Given the central role of UVRAG in genomic stability and autophagic cleaning, it is speculated that UVRAG is a bona fide genome protector and that the decrease in UVRAG seen in some cancers may render these cells vulnerable to chromosomal damage, making UVRAG an appealing target for cancer therapy.

PMID:
22885520
PMCID:
PMC3442888
DOI:
10.4161/auto.21035
[Indexed for MEDLINE]
Free PMC Article

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