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Bioorg Med Chem Lett. 2012 Sep 15;22(18):5915-8. doi: 10.1016/j.bmcl.2012.07.069. Epub 2012 Jul 27.

Antiplasmodial activities of 4-aminoquinoline-statine compounds.

Author information

1
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

Abstract

We report the discovery of new potent inhibitors of the growth of Plasmodium falciparum chloroquine (CQ)-resistant W2 strain. These compounds were designed using the double drug approach by introducing a residue able to enhance the accumulation of plasmepsins inhibitors into the food vacuole. Some of the molecules were more active than CQ against CQ-resistant strain and showed good selectivity against cathepsin D.

PMID:
22884991
DOI:
10.1016/j.bmcl.2012.07.069
[Indexed for MEDLINE]

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