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FEBS Lett. 2012 Sep 21;586(19):3208-14. doi: 10.1016/j.febslet.2012.07.014. Epub 2012 Jul 31.

Kinetic properties and small-molecule inhibition of human myosin-6.

Author information

1
Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.

Abstract

Myosin-6 is an actin-based motor protein that moves its cargo towards the minus-end of actin filaments. Mutations in the gene encoding the myosin-6 heavy chain and changes in the cellular abundance of the protein have been linked to hypertrophic cardiomyopathy, neurodegenerative diseases, and cancer. Here, we present a detailed kinetic characterization of the human myosin-6 motor domain, describe the effect of 2,4,6-triiodophenol on the interaction of myosin-6 with F-actin and nucleotides, and show how addition of the drug reduces the number of myosin-6-dependent vesicle fusion events at the plasma membrane during constitutive secretion.

PMID:
22884421
PMCID:
PMC3527664
DOI:
10.1016/j.febslet.2012.07.014
[Indexed for MEDLINE]
Free PMC Article
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