Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Transl Sci. 2012 Aug;5(4):314-20. doi: 10.1111/j.1752-8062.2012.00421.x. Epub 2012 Jun 1.

Use of the dietary supplement 5-aminiolevulinic acid (5-ALA) and its relationship with glucose levels and hemoglobin A1C among individuals with prediabetes.

Author information

1
Department of Complementary and Alternative Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.

Abstract

OBJECTIVE:

This study examined the association between 5-aminolevulinic acid (5-ALA) and glucose tolerance.

DESIGN:

A double blinded, randomized prospective parallel-group comparison study.

SETTING:

Participants were recruited from the community in Honolulu, Hawaii, using radio and TV ads, and at community events.

PARTICIPANTS:

One hundred fifty-four males and females ages 40-70 years, with evidence of prediabetes: hemoglobin A1c (HbA1c) 5.8%-7.0% at the screening visit.

INTERVENTION:

Participants were randomized equally to one of three study groups: (1) low dose 5-ALA supplement (15 mg capsule); (2) high dose 5-ALA (50 mg capsule); and (3) control (placebo capsule of identical size and color).

MAIN OUTCOME MEASURES:

HbA1c and 2 hours post-oral glucose tolerance test (OGTT) glucose levels.

RESULTS:

Among individuals taking 5-ALA supplements for 12 weeks, 2 hours post-OGTT glucose levels declined significantly compared to those not taking the supplement (p= 0.02). The relationships were stronger among those with baseline glucose intolerance, or 2 hours post-OGTT glucose measurements greater than 140 mg/dL (p= 0.005 and p= 0.02 for the low and high dose group, respectively). Similar trends were observed for HbA1c but results were of borderline significance (p= 0.07). No untoward effects were reported.

CONCLUSIONS:

Further studies are indicated. The potential benefits of 5-ALA dietary supplementation are affirmed by this investigation.

PMID:
22883608
PMCID:
PMC5439781
DOI:
10.1111/j.1752-8062.2012.00421.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center