[Role of vasculogenic mimicry and endothelium-dependent vessel in metastasis of laryngeal cancer]

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):400-5.
[Article in Chinese]

Abstract

Objective: To investigate the contribution of vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) to invasion and metastasis of laryngeal squamous cell carcinoma (LSCC).

Methods: A total of 203 cases with LSCC was reviewed and followed up. VM and EDV in LSCC tissues were assessed by double staining with anti-CD31 immunohistochemistry and periodic acid-schiff. Kruskal-Wallis test and one-way ANOVA were used to analyze the relationship between VM, EDV and clinical pathology parameters of LSCC. Kaplan-Meier analysis was used to evaluate overall survival (OS) of patients with LSCC.

Results: VM related to pTNM stage, lymph node metastasis and pathology grade of LSCC, while EDV related to primary sites, pTNM stage, T stage and distant metastasis of LSCC. Univariate analysis showed VM (P = 0.014), pTNM stage (P = 0.009), T stage (P = 0.013), nodal status (P = 0.013), histopathology grade (P = 0.038), tumor size (P = 0.028), and radiotherapy (P < 0.0001) related to OS. VM (P = 0.011), primary sites (P = 0.049), tumor size (P = 0.001) and radiotherapy (P < 0.0001) related to disease free survival. Multivariate analysis indicated that VM was an adverse predictor for both OS and disease free survival.

Conclusions: Both VM and EDV existed in LSCC. VM contributed to progression of LSCC through promoting lymph node metastasis. VM is an independent predictor for the prognosis of LSCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / blood supply*
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / pathology
  • Endothelium, Vascular
  • Female
  • Head and Neck Neoplasms / blood supply*
  • Head and Neck Neoplasms / diagnosis
  • Head and Neck Neoplasms / pathology
  • Humans
  • Laryngeal Neoplasms / blood supply*
  • Laryngeal Neoplasms / diagnosis
  • Laryngeal Neoplasms / pathology
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neovascularization, Pathologic
  • Prognosis
  • Retrospective Studies
  • Squamous Cell Carcinoma of Head and Neck