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Cell Metab. 2012 Aug 8;16(2):141-3. doi: 10.1016/j.cmet.2012.07.013.

The mitochondrial pyruvate carrier: has it been unearthed at last?

Author information

1
School of Biochemistry, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK. a.halestrap@bristol.ac.uk

Abstract

The mitochondrial pyruvate carrier (MPC) is essential for several major pathways of carbohydrate, fat, and amino acid metabolism, yet its molecular identity has remained elusive. Two recent papers in Science (Herzig et al., 2012; Bricker et al., 2012) implicate three newly identified inner mitochondrial membrane proteins as MPC components.

PMID:
22883228
DOI:
10.1016/j.cmet.2012.07.013
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