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J Vet Pharmacol Ther. 2013 Oct;36(5):502-6. doi: 10.1111/j.1365-2885.2012.01426.x. Epub 2012 Aug 8.

Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus).

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Mississippi State University College of Veterinary Medicine, Stoneville, MS, USA.


Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half-life (t(1/2)), maximum concentration at steady-state (Css (max)), time of Css (max) (T(max)), minimal concentration at steady-state (Css (min)), and Vc /F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of <2.5 μg/mL.

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