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PLoS One. 2012;7(8):e42647. doi: 10.1371/journal.pone.0042647. Epub 2012 Aug 3.

Melanopsin mediates retrograde visual signaling in the retina.

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1
Eye Research Institute, Oakland University, Rochester, Michigan, United States of America. zhang@oakland.edu

Abstract

The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits.

PMID:
22880066
PMCID:
PMC3411794
DOI:
10.1371/journal.pone.0042647
[Indexed for MEDLINE]
Free PMC Article
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