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PLoS One. 2012;7(8):e42549. doi: 10.1371/journal.pone.0042549. Epub 2012 Aug 6.

Galectin-10, a potential biomarker of eosinophilic airway inflammation.

Author information

1
Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia.

Abstract

Measurement of eosinophilic airway inflammation can assist in the diagnosis of allergic asthma and in the management of exacerbations, however its clinical implementation remains difficult. Galectin-10 has been associated with eosinophilic inflammation and has the potential to be used as a surrogate biomarker. This study aimed to assess the relationship between galectin-10 in sputum with sputum eosinophil counts, the current gold standard of eosinophil inflammation in the lung. Thirty-eight sputum samples were processed for both eosinophil counts by cytospins and semi-quantitative measurements of galectin-10 by western blots. A strong association was observed between galectin-10 levels in sputum and sputum eosinophil measurements, and they accurately determined sputum eosinophilia. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.

PMID:
22880030
PMCID:
PMC3412795
DOI:
10.1371/journal.pone.0042549
[Indexed for MEDLINE]
Free PMC Article

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