Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2012 Aug;191(4):1041-72. doi: 10.1534/genetics.111.137760.

Prions in yeast.

Author information

  • 1Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA. suel@uic.edu

Abstract

The concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the "protein only" model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-β aggregates (amyloids). Recently, there has been an explosion in the number of recognized prions in yeast. Yeast continues to lead the way in understanding cellular control of prion propagation, prion structure, mechanisms of de novo prion formation, specificity of prion transmission, and the biological roles of prions. This review summarizes what has been learned from yeast prions.

PMID:
22879407
PMCID:
PMC3415993
DOI:
10.1534/genetics.111.137760
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center