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EMBO Rep. 2012 Oct;13(10):916-22. doi: 10.1038/embor.2012.116. Epub 2012 Aug 10.

Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins.

Author information

1
Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, UK.

Abstract

Thiol-disulphide redox regulation has a key role during the biogenesis of mitochondrial intermembrane space (IMS) proteins. Only the Cys-reduced form of precursor proteins can be imported into mitochondria, which is followed by disulphide bond formation in the mitochondrial IMS. In contrast to the wealth of knowledge on the oxidation process inside mitochondria, little is known about how precursors are maintained in an import-competent form in the cytosol. Here we provide the first evidence that the cytosolic thioredoxin system is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import during respiratory growth.

PMID:
22878414
PMCID:
PMC3463972
DOI:
10.1038/embor.2012.116
[Indexed for MEDLINE]
Free PMC Article

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