Format

Send to

Choose Destination
Int J Dev Neurosci. 2012 Oct;30(6):435-8. doi: 10.1016/j.ijdevneu.2012.07.004. Epub 2012 Aug 1.

Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child.

Author information

1
AGC Pediatría, Hospital Universitario Central de Asturias, Spain. msr1070@hotmail.com

Abstract

CONTEXT:

Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.

OBJECTIVE:

The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.

MATERIALS AND METHODS:

The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.

RESULTS:

54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.

PMID:
22877976
DOI:
10.1016/j.ijdevneu.2012.07.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center