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Endocrinol Metab Clin North Am. 2012 Sep;41(3):557-69. doi: 10.1016/j.ecl.2012.04.003. Epub 2012 May 22.

How vitamin D works on bone.

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Division of Endocrinology, Diabetes and Metabolism, Chiba University Hospital, 1-8-1 Inohana, Chiba-shi, Chiba 260-8670, Japan.


Vitamin D is important for the normal development and maintenance of bone. The elucidation of the vitamin D activation pathway and the cloning of the vitamin D receptor have advanced our understanding of the actions of vitamin D on bone. The preponderance of evidence indicates that 1,25(OH)₂D₃ enhances bone mineralization through its effects to promote calcium and phosphate absorption. Although 1,25(OH)₂D₃ stimulates bone resorption in vitro, treatment in vivo can prevent bone loss and fracture through several potential mechanisms. The development of vitamin D analogues has provided new therapeutic options for increasing bone mineral density and reducing fractures.

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