Format

Send to

Choose Destination
See comment in PubMed Commons below
J Leukoc Biol. 2012 Nov;92(5):959-75. doi: 10.1189/jlb.0212100. Epub 2012 Aug 8.

The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes.

Author information

1
Department of Immunology, Erasmus MC, Rotterdam, the Netherlands. w.beumer@erasmusmc.nl

Abstract

This review describes a key role for mononuclear phagocytes in the pathogenesis of major psychiatric disorders. There is accumulating evidence for activation of microglia (histopathology and PET scans) and circulating monocytes (enhanced gene expression of immune genes, an overproduction of monocyte/macrophage-related cytokines) in patients with bipolar disorder, major depressive disorder, and schizophrenia. These data are strengthened by observations in animal models, such as the MIA models, the chronic stress models, and the NOD mouse model. In these animal models of depressive-, anxiety-, and schizophrenia-like behavior, similar activations of microglia and circulating monocytes can be found. These animal models also make in-depth pathogenic studies possible and show that microglia activation impacts neuronal development and function in brain areas congruent with the altered depressive and schizophrenia-like behaviors.

PMID:
22875882
DOI:
10.1189/jlb.0212100
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center