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Epidemiol Infect. 2013 Apr;141(4):827-32. doi: 10.1017/S095026881200129X. Epub 2012 Jul 3.

Human metapneumovirus infection among family members.

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Department of Infectious Diseases, Yamagata University Faculty of Medicine, Iida-nishi 2-2-2, Yamagata, Japan.


The transmission of human metapneumovirus (hMPV) among family members is not well understood. We identified 15 families in which multiple members were diagnosed with hMPV infection by real-time PCR in 2008 and 2010. Index patients ranged in age from 2 years to 11 years (median 5 years), and all 15 index cases were children who attended primary school, kindergarten, or nursery school. Contact patients ranged in age from 2 months to 46 years (median 6 years). Excluding five adult cases, contact patients were significantly younger than index patients (P = 0ยท0389). Of the 12 contact children, seven (58%) were infants who were taken care of at home. The serial interval between the onset of symptoms in an index patient and the onset of symptoms in a contact patient was estimated to be 5 days. These results suggest that the control of school-based outbreaks is important for preventing hMPV infection in infants.

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