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Mol Cell Endocrinol. 2013 Jul 5;373(1-2):51-60. doi: 10.1016/j.mce.2012.07.011. Epub 2012 Jul 31.

Disordered follicle development.

Author information

1
Division of Reproductive Endocrinology, Department of Reproductive Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0633, United States. rjchang@ucsd.edu

Abstract

Alterations of ovarian follicle morphology and function have been well documented in women with PCOS. These include increased numbers of growing preantral follicles, failure of follicle growth beyond the mid-antral stage, evidence of granulosa call degeneration, and theca cell hyperplasia. Functional abnormalities include paradoxical granulosa cell hyperresponsiveness to FSH which is clinically linked to ovarian hyperstimulation during ovulation induction. In addition, there is likely a primary theca cell defect that accounts for the majority of excess androgen production in this disorder. The precise mechanisms responsible for altered follicle function are not completely clear. However, several factors appear to influence normal advancement of follicle development as well as impair ovarian steroidogenesis. These include intra- as well as extraovarian influences that distort normal ovarian growth and disrupt steroid production by follicle cells.

PMID:
22874072
PMCID:
PMC3727408
DOI:
10.1016/j.mce.2012.07.011
[Indexed for MEDLINE]
Free PMC Article

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