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Clin Pharmacol Ther. 2012 Sep;92(3):340-8. doi: 10.1038/clpt.2012.110. Epub 2012 Aug 8.

Nrf2: a potential target for new therapeutics in liver disease.

Author information

1
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.

Abstract

Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.

PMID:
22871994
PMCID:
PMC3704160
DOI:
10.1038/clpt.2012.110
[Indexed for MEDLINE]
Free PMC Article

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