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J Cell Biol. 2012 Aug 6;198(3):277-9. doi: 10.1083/jcb.201207076.

A first line of defense against ER stress.

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1
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA.

Abstract

BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of BiP provides a reversible switch that fine tunes BiP activity according to need.

PMID:
22869593
PMCID:
PMC3413362
DOI:
10.1083/jcb.201207076
[Indexed for MEDLINE]
Free PMC Article
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