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Diabetologia. 2012 Oct;55(10):2660-2666. doi: 10.1007/s00125-012-2655-5. Epub 2012 Aug 7.

Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.

Author information

1
Department of Maternal and Child Health Care, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan, 250012, People's Republic of China. xibo2007@126.com.
2
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
3
Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.
4
Department of Ophthalmology, Medical College, Jinan University, Guangzhou, China.
5
Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, People's Republic of China.
6
Department of Endocrinology, Linyi People's Hospital, Linyi, People's Republic of China.
7
Department of Epidemiology and Biostatistics, Guangdong Medical College, Dongwan, People's Republic of China.
8
Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Road, Beijing, 100020, People's Republic of China. jiemi@vip.163.com.

Abstract

AIMS/HYPOTHESIS:

Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans. As obesity is associated with an increased risk of type 2 diabetes, many studies have investigated the association between polymorphisms near the MC4R gene and type 2 diabetes risk across different ethnic populations, with inconsistent results. In this study, we performed a meta-analysis to clarify the association of variants near MC4R with type 2 diabetes risk.

METHODS:

Published literature from PubMed and Embase was retrieved. All studies that evaluated the association of at least one of the two MC4R polymorphism(s) with type 2 diabetes were included in the study. Pooled ORs with 95% CIs were calculated using the fixed-effects model.

RESULTS:

A total of 19 studies (comprising 34,195 cases and 89,178 controls) of the rs17782313 polymorphism (or its proxy rs12970134) were included in the meta-analysis. The results indicated that the rs17782313 polymorphism was significantly associated with type 2 diabetes risk among the overall study population (OR 1.10, 95% CI 1.07, 1.13, p = 2.83 × 10(-12) [Z test], I(2) = 9.1%, p = 0.345 [heterogeneity]). The association remained significant even after adjustment for body mass index (BMI) (OR 1.06, 95% CI 1.03, 1.09, p = 2.14 × 10(-5) [Z test], I(2) = 4.9%, p = 0.397 [heterogeneity]). Further sensitivity analysis confirmed the statistically significant association of rs17782313 polymorphism with type 2 diabetes, and no publication bias was detected.

CONCLUSIONS/INTERPRETATION:

The present meta-analysis confirmed the significant association of the rs17782313 polymorphism near the MC4R gene with type 2 diabetes risk, which was independent of BMI.

PMID:
22869321
DOI:
10.1007/s00125-012-2655-5
[Indexed for MEDLINE]

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