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Am J Obstet Gynecol. 2012 Oct;207(4):331.e1-6. doi: 10.1016/j.ajog.2012.06.064. Epub 2012 Aug 4.

Transplacental transfer of vancomycin and telavancin.

Author information

1
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.

Abstract

OBJECTIVE:

We sought to determine the bidirectional transfer and distribution of vancomycin and telavancin across the dually perfused term human placental lobule.

STUDY DESIGN:

The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry.

RESULTS:

In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters.

CONCLUSION:

The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.

PMID:
22867688
PMCID:
PMC3891835
DOI:
10.1016/j.ajog.2012.06.064
[Indexed for MEDLINE]
Free PMC Article

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