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Ann Behav Med. 2012 Dec;44(3):301-8. doi: 10.1007/s12160-012-9393-2.

Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.

Author information

1
Departments of Nutritional Sciences (ACS, PMKE, SGW) and Biobehavioral Health (SGW), Pennsylvania State University, University Park, PA 16802, USA.

Abstract

BACKGROUND:

Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms.

PURPOSE:

We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks.

METHODS:

This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults.

RESULTS:

Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids.

CONCLUSIONS:

High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).

PMID:
22865498
PMCID:
PMC3653417
DOI:
10.1007/s12160-012-9393-2
[Indexed for MEDLINE]
Free PMC Article

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