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Curr Gastroenterol Rep. 2012 Oct;14(5):428-38. doi: 10.1007/s11894-012-0280-6.

Familial colon cancer syndromes: an update of a rapidly evolving field.

Author information

1
University of Colorado School of Medicine, Aurora, CO 80045, USA. Swati.Patel@ucdenver.edu

Abstract

Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 % of CRCs have evidence of a familial component, and about 5 % are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development.

PMID:
22864806
PMCID:
PMC3448005
DOI:
10.1007/s11894-012-0280-6
[Indexed for MEDLINE]
Free PMC Article

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