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MAGMA. 2013 Feb;26(1):71-9. doi: 10.1007/s10334-012-0329-4. Epub 2012 Aug 3.

In-vivo human brain molecular imaging with a brain-dedicated PET/MRI system.

Author information

1
Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea. zcho@gachon.ac.kr

Abstract

Advances in the new-generation of ultra-high-resolution, brain-dedicated positron emission tomography-magnetic resonance imaging (PET/MRI) systems have begun to provide many interesting insights into the molecular dynamics of the brain. First, the finely delineated structural information from ultra-high-field MRI can help us to identify accurate landmark structures, thereby making it easier to locate PET activation sites that are anatomically well-correlated with metabolic or ligand-specific organs in the neural structures in the brain. This synergistic potential of PET/MRI imaging is discussed in terms of neuroscience and neurological research from both translational and basic research perspectives. Experimental results from the hippocampus, thalamus, and brainstem obtained with (18)F-fluorodeoxyglucose and (11)C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile are used to demonstrate the potential of this new brain PET/MRI system.

PMID:
22864642
DOI:
10.1007/s10334-012-0329-4
[Indexed for MEDLINE]

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