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Nat Rev Microbiol. 2012 Sep;10(9):599-606. doi: 10.1038/nrmicro2850. Epub 2012 Aug 6.

High-throughput bacterial genome sequencing: an embarrassment of choice, a world of opportunity.

Author information

1
Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.

Abstract

Here, we take a snapshot of the high-throughput sequencing platforms, together with the relevant analytical tools, that are available to microbiologists in 2012, and evaluate the strengths and weaknesses of these platforms in obtaining bacterial genome sequences. We also scan the horizon of future possibilities, speculating on how the availability of sequencing that is 'too cheap to metre' might change the face of microbiology forever.

PMID:
22864262
DOI:
10.1038/nrmicro2850
[Indexed for MEDLINE]

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