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Gastroenterology. 2012 Nov;143(5):1173-1175.e7. doi: 10.1053/j.gastro.2012.07.110. Epub 2012 Aug 1.

A porcine model of familial adenomatous polyposis.

Author information

1
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
2
Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
3
Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
4
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany. Electronic address: schnieke@wzw.tum.de.

Abstract

We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.

PMID:
22864254
DOI:
10.1053/j.gastro.2012.07.110
[Indexed for MEDLINE]

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