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Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):e41-7. doi: 10.1016/j.oooo.2012.01.021. Epub 2012 May 12.

Nonsebaceous lymphadenoma of salivary gland: report of a case with immunohistochemistry and review of the literature.

Author information

1
Department of Medical Science, Dentistry, and Biophysics, University of Genoa, Genoa, Italy. f.angiero@teos.it

Abstract

OBJECTIVE:

Nonsebaceous lymphadenomas are rare benign neoplasms. We emphasize the role of immunohistochemistry and attempt to elucidate the pathogenesis by investigating the distribution of 2 transcription factors, MYC and BLIMP1.

STUDY DESIGN:

A 70-year-old man was evaluated for a 3-cm left parotid mass. Ultrasound-guided fine-needle aspiration biopsy findings were suggestive of a diagnosis of pleomorphic adenoma. A left superficial parotidectomy was performed, and based on histopathology a diagnosis of lymphadenoma, nonsebaceous type, was rendered.

RESULTS:

The tumor was positive for AE1/3, CKA, BclII, P63, CD79a, CD3, and MYC; focally positive for CK7 and epithelial membrane antigen; and negative for CD10, calponin, CD117, and BLIMP1.

CONCLUSIONS:

The rarity of nonsebaceous lymphadenoma and its superficial resemblance to commoner salivary gland tumors may present a diagnostic challenge for pathologists. The expression of MYC in the ductal component and the differentiation-related expression of PRDM1 in the superficial keratinizing layers point to a potential role for these 2 transcription factors in the pathogenesis of this neoplasm.

PMID:
22862989
DOI:
10.1016/j.oooo.2012.01.021
[Indexed for MEDLINE]

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