Send to

Choose Destination
See comment in PubMed Commons below
Cell Stem Cell. 2012 Aug 3;11(2):153-61. doi: 10.1016/j.stem.2012.07.015.

How can human pluripotent stem cells help decipher and cure Huntington's disease?

Author information

  • 1INSERM U861, I-Stem/AFM, 5 rue Henri Desbru√®res Evry, 91030 Cedex, France.


Pluripotent stem cell (PSC) technologies are becoming a key asset for deciphering pathological cascades and for developing new treatments against many neurodegenerative disorders, including Huntington's disease (HD). This perspective discusses the challenges and opportunities facing the use of PSCs for treating HD, focusing on four major applications: namely, the use of PSCs as a substitute source of human striatal cells for current HD cell therapy, as a cellular model of HD for the validation of human-specific gene therapies, for deciphering molecular mechanisms underlying HD, and in drug discovery.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center