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ACS Chem Neurosci. 2012 May 16;3(5):349-55. doi: 10.1021/cn300014e. Epub 2012 Mar 3.

Endocannabinoid signaling in female reproduction.

Author information

1
Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, Ohio 45229, United States.

Abstract

Marijuana is a preparation of the flower, as well as the leaves and seeds, of the plant Cannabis sativa. Marijuana has been used for medicinal and recreational purposes for thousands of years due to its psychoactive effects including euphoria, sedation, and analgesia. Although it has been suspected for decades that marijuana has adverse effects on female fertility, the underlying molecular mechanism was not clear. The discovery of cannabinoid receptors and endocannabinoids has advanced studies if cannabinoid signaling. Since then, numerous studies have been published on cannabinoid signaling in female reproductive events, including preimplantation embryo development, oviductal embryo transport, embryo implantation, placentation, and parturition. This review focuses on various aspects of endocannabinoid signaling in female fertility.

KEYWORDS:

Cannabinoids; embryo; implantation; oviduct; placentation; uterus

PMID:
22860202
PMCID:
PMC3382454
DOI:
10.1021/cn300014e
[Indexed for MEDLINE]
Free PMC Article

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