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ACS Chem Neurosci. 2011 Sep 21;2(9):536-43. doi: 10.1021/cn200037p. Epub 2011 Jun 9.

Tuning photochromic ion channel blockers.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

Abstract

Photochromic channel blockers provide a conceptually simple and convenient way to modulate neuronal activity with light. We have recently described a family of azobenzenes that function as tonic blockers of K(v) channels but require UV-A light to unblock and need to be actively switched by toggling between two different wavelengths. We now introduce red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark. Furthermore, we have developed a version that does not block effectively in the dark-adapted state, can be switched to a blocking state with blue light, and reverts to the inactive state automatically. Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions.

KEYWORDS:

azobenzenes; ion channel blockers; photochromic molecules; photopharmacology; voltage-gated potassium channels

PMID:
22860175
PMCID:
PMC3401033
DOI:
10.1021/cn200037p
[Indexed for MEDLINE]
Free PMC Article

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