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Ther Adv Musculoskelet Dis. 2012 Aug;4(4):245-7. doi: 10.1177/1759720X12441275.

Biologicals and bone loss.

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Department of Rheumatology, Jan van Breemen Research Institute/Reade, Amsterdam, The Netherlands.


Inflammatory joint diseases are associated with extra-articular side effects including bone involvement.There is an increased risk of osteoporotic fractures. The pathogeneses of local and generalized bone loss share a common pathway. Early and active rheumatoid arthritis is associated with longitudinal observed bone loss and fracture rate is of vertebral and nonvertebral fractures is doubled compared with matched healthy controls. Lowering disease activity with TNF inhibitors or is associated with stabilisation of bone mineral density by counteracting elevated bone resorption.


ankylosing spondylitis biologicals; bone mineral density; fracture risk; osteoporosis; rheumatoid arthritis

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