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Clin Cancer Res. 2012 Aug 15;18(16):4219-21. doi: 10.1158/1078-0432.CCR-12-1713. Epub 2012 Aug 2.

Might cigarettes be a "smoking gun" to reduce taxane myelotoxicity?

Author information

1
Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. lionel.lewis@dartmouth.edu

Abstract

de Graan and colleagues report a retrospective study of the effects of cigarette smoking on taxane pharmacokinetics and myelosuppression. There was no difference in taxane pharmacokinetic clearance between smokers and nonsmokers. Further prospective studies of the effects of cigarette smoking on myelosuppression would be of interest.

PMID:
22859717
PMCID:
PMC3440763
DOI:
10.1158/1078-0432.CCR-12-1713
[Indexed for MEDLINE]
Free PMC Article
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