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Lab Chip. 2012 Sep 21;12(18):3285-9. doi: 10.1039/c2lc40611j. Epub 2012 Aug 2.

Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies.

Author information

1
Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr, Stuttgart, 370569, Germany. kruss@is.mpg.de

Abstract

We report on a method to fabricate biofunctionalized polyethylene glycol hydrogel microchannels with adjustable circular cross-sections. The inner channel surfaces are decorated with Au-nanoparticle arrays of tunable density. These Au-nanoparticles are functionalized with biomolecules whereas the hydrogel material provides an inert and biocompatible background. This technology provides control over flow conditions, channel curvature and biomolecule density on the channel surface. It can be applied for biophysical studies of cell-surface interactions mimicking, for example, leukocyte interactions with the endothelial lining in small vessels.

PMID:
22858992
PMCID:
PMC3448975
DOI:
10.1039/c2lc40611j
[Indexed for MEDLINE]
Free PMC Article

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