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Molecules. 2012 Aug 2;17(8):9258-73. doi: 10.3390/molecules17089258.

Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.

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1
Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, NO-0027 Oslo, Norway. jorrit.enserink@rr-research.no

Abstract

The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.

PMID:
22858845
DOI:
10.3390/molecules17089258
[Indexed for MEDLINE]
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