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Pediatr Emerg Care. 2012 Aug;28(8):767-70.

Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.

Author information

1
Division of Pediatric Emergency Medicine, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA. dst2141@columbia.edu

Abstract

OBJECTIVE:

The objective of this study was to compare the efficacy of 3 doses of intranasal ketamine (INK) for sedation of children from 1 to 7 years old requiring laceration repair.

METHODS:

This was a randomized, prospective, double-blind trial of children requiring sedation for laceration repair. Patients with simple lacerations were randomized by age to receive 3, 6, or 9 mg/kg INK. Adequacy and efficacy of sedation were measured with the Ramsay sedation score and the Observational Scale of Behavioral Distress-Revised. Serum ketamine and norketamine levels were drawn during the procedure. Sedation duration and adverse events were recorded.

RESULTS:

Of the 12 patients enrolled, 3 patients achieved adequate sedation, all at the 9-mg/kg dose. The study was suspended at that time as per predetermined criteria.

CONCLUSIONS:

Nine milligrams of INK per kilogram produced a significantly higher proportion of successful sedations than the 3- and 6-mg/kg doses.

PMID:
22858745
DOI:
10.1097/PEC.0b013e3182624935
[Indexed for MEDLINE]

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