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Chem Commun (Camb). 2012 Sep 18;48(72):9053-5. doi: 10.1039/c2cc34816k. Epub 2012 Aug 2.

Semisynthetic peptide-lipase conjugates for improved biotransformations.

Author information

1
Departamento de Biocatálisis, Instituto de Catálisis (CSIC), Marie Curie 2, Cantoblanco, CampusUAM, 28049 Madrid, Spain.

Abstract

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

PMID:
22858661
DOI:
10.1039/c2cc34816k
[Indexed for MEDLINE]

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