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Curr Opin Pharmacol. 2012 Oct;12(5):623-8. doi: 10.1016/j.coph.2012.07.011. Epub 2012 Jul 31.

Systems biology: personalized medicine for the future?

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1
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.

Abstract

Systems biology is actively transforming the field of modern health care from symptom-based disease diagnosis and treatment to precision medicine in which patients are treated based on their individual characteristics. Development of high-throughput technologies such as high-throughout sequencing and mass spectrometry has enabled scientists and clinicians to examine genomes, transcriptomes, proteomes, metabolomes, and other omics information in unprecedented detail. The combined 'omics' information leads to a global profiling of health and disease, and provides new approaches for personalized health monitoring and preventative medicine. In this article, we review the efforts of systems biology in personalized medicine in the past 2 years, and discuss in detail achievements and concerns, as well as highlights and hurdles for future personalized health care.

PMID:
22858243
PMCID:
PMC4076046
DOI:
10.1016/j.coph.2012.07.011
[Indexed for MEDLINE]
Free PMC Article
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