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Bioorg Med Chem Lett. 2012 Sep 1;22(17):5527-31. doi: 10.1016/j.bmcl.2012.07.030. Epub 2012 Jul 15.

Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.

Author information

1
Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland.

Abstract

Iron chelators have emerged as a potential anti-cancer treatment strategy. In this study, a series of novel thiosemicarbazone iron chelators containing a quinoline scaffold were synthesized and characterized. A number of analogs show markedly greater anti-cancer activity than the 'gold-standard' iron chelator, desferrioxamine. The anti-proliferative activity and iron chelation efficacy of several of these ligands (especially compound 1b), indicates that further investigation of this class of thiosemicarbazones is worthwhile.

PMID:
22858101
DOI:
10.1016/j.bmcl.2012.07.030
[Indexed for MEDLINE]

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