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J Antimicrob Chemother. 2012 Dec;67(12):2870-2. doi: 10.1093/jac/dks305. Epub 2012 Jul 31.

Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity.

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1
Department of Pediatrics, Division of Infectious Diseases, Columbia University, New York, NY 10032, USA.

Abstract

BACKGROUND:

Retrocyclins are cyclic antimicrobial peptides that have been shown to be both broadly active and safe in animal models. RC-101, a synthetic retrocyclin, targets important human pathogens and is a candidate vaginal microbicide. Its activity against microbes associated with bacterial vaginosis is unknown.

METHODS:

We investigated the effect of RC-101 on toxin activity, bacterial growth and biofilm formation of Gardnerella vaginalis in vitro.

RESULTS:

RC-101 potently inhibits the cytolytic activity of vaginolysin, the Gardnerella vaginalis toxin, on both erythrocytes and nucleated cells. RC-101 lacks inhibitory activity against planktonic G. vaginalis but markedly decreases biofilm formation.

CONCLUSIONS:

These dual properties, toxin inhibition and biofilm retardation, justify further exploration of RC-101 as a candidate agent for bacterial vaginosis prevention.

PMID:
22855857
PMCID:
PMC3494843
DOI:
10.1093/jac/dks305
[Indexed for MEDLINE]
Free PMC Article
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