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Genes Dev. 2012 Aug 1;26(15):1685-90. doi: 10.1101/gad.193433.112.

Unraveling the KNOTTED1 regulatory network in maize meristems.

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1
Plant Gene Expression Center, U.S. Department of Agriculture-Agricultural Research Service, Plant and Microbial Biology Department, University of California at Berkeley, 94720, USA.

Abstract

KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors function in plant meristems, self-renewing structures consisting of stem cells and their immediate daughters. We defined the KN1 cistrome in maize inflorescences and found that KN1 binds to several thousand loci, including 643 genes that are modulated in one or multiple tissues. These KN1 direct targets are strongly enriched for transcription factors (including other homeobox genes) and genes participating in hormonal pathways, most significantly auxin, demonstrating that KN1 plays a key role in orchestrating the upper levels of a hierarchical gene regulatory network that impacts plant meristem identity and function.

PMID:
22855831
PMCID:
PMC3418586
DOI:
10.1101/gad.193433.112
[Indexed for MEDLINE]
Free PMC Article
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