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Genes Dev. 2012 Aug 1;26(15):1648-52. doi: 10.1101/gad.199059.112.

Blunt-ended telomeres: an alternative ending to the replication and end protection stories.

Author information

1
Department of Biochemistry and Biophysics, Texas A&M University, College Station, 77843, USA.

Abstract

Telomeres ensure the complete replication of genetic material while simultaneously distinguishing the chromosome terminus from a double-strand break. A prevailing theme in telomere biology is that the two chromosome ends are symmetrical. Both terminate in a single-strand 3' extension, and the 3' extension is crucial for telomere end protection. In this issue of Genes & Development, Kazda and colleagues (pp. 1703-1713) challenge this paradigm using a series of elegant biochemical and genetic assays to demonstrate that half of the chromosomes in flowering plants are blunt-ended. This discovery reveals unanticipated complexity in telomeric DNA processing and a novel mode of chromosome end protection.

PMID:
22855827
PMCID:
PMC3418582
DOI:
10.1101/gad.199059.112
[Indexed for MEDLINE]
Free PMC Article

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