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Nat Cell Biol. 2012 Aug;14(8):777-83. doi: 10.1038/ncb2548.

Classifying collective cancer cell invasion.

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1
Department of Cell Biology, NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

Abstract

Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.

PMID:
22854810
DOI:
10.1038/ncb2548
[Indexed for MEDLINE]
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