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Hum Vaccin Immunother. 2012 Aug;8(8):1082-9. doi: 10.4161/hv.20759. Epub 2012 Aug 1.

Comparison of stimulating effect on subpopulations of lymphocytes in human peripheral blood by methionine enkephalin with IL-2 and IFN-γ.

Author information

1
Department of Immunology; School of Basic Medical Science; China Medical University, Shenyang, China.

Abstract

The aim of this study was to investigate the effects of mechanisms of methionine enkephalin (MENK) on lymphocytes in human peripheral blood. We detected CD4+T cells, CD8+T cells, CD4+CD25+ regulatory T cells (Treg), dendritic cells (DCs), natural killer cells (NK), NKT cells and γδT cells before and after treatment with 10 (-12) M MENK, in cell culture by FCM and RT-PCR. Our findings show that MENK stimulating expansion of lymphocyte subpopulationns by inhibiting CD4+CD25+ regulatory T cells (Treg), which is unique discovery of our study. We may use MENK as a drug to treat cancer patients, whose immune systems are damaged by chemotherapy or radiotherapy.

PMID:
22854663
PMCID:
PMC3551880
DOI:
10.4161/hv.20759
[Indexed for MEDLINE]
Free PMC Article

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