Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Hypertens. 2012 Nov;25(11):1188-94. doi: 10.1038/ajh.2012.106. Epub 2012 Aug 2.

Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.

Author information

1
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. vbhatnag@ucsd.edu

Abstract

BACKGROUND:

Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP).

METHODS:

Outpatient blood pressure data over an approximate 8-year period was collected from the Veterans Affairs Hypertensive Cohort (N = 1,302). Association between genotype and longitudinal MAP was further explored using a random effects model controlling for age, ancestry, renal function, and other determinants of blood pressure. To control for population stratification, principal component groupings based on ancestry informative markers in this dataset were included as covariates (in addition to self-identified ancestry). Data from the African American Study of Kidney Disease and Hypertension (AASK, N = 857) was used to confirm significant findings in an independent cohort.

RESULTS:

There was a significant interaction between PON1-108 C/T genotype and follow-up age group. At a younger age (<50 years), there was an estimated 2.53 mm Hg (95% confidence interval: 1.06, 4.00) increase in MAP with each additional C-allele. At the older age groups, there were no significant associations between PON1-108 C/T genotype and MAP. Using data from the AASK trial, the C-allele at PON1-108 C/T was significantly associated with a higher MAP (P = 0.005) but only among younger participants (<54 years).

CONCLUSIONS:

The PON1-108 polymorphism may be associated with MAP in an age-dependent manner.

PMID:
22854640
PMCID:
PMC3515680
DOI:
10.1038/ajh.2012.106
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center