Format

Send to

Choose Destination
Immunotherapy. 2012 Jul;4(7):703-18. doi: 10.2217/imt.12.40.

Dendritic cell engineering for tumor immunotherapy: from biology to clinical translation.

Author information

1
Division of Translational Research, Tata Memorial Centre, ACTREC, India.

Abstract

Dendritic cells (DCs) are the most potent APCs, with the ability to orchestrate a repertoire of immune responses. DCs play a pivotal role in the initiation, programming and regulation of tumor-specific immune responses, as they are poised to take up, process and present tumor antigens to naive or effector T lymphocytes. Although, to an extent, DC-based immunotherapeutic strategies have successfully induced specific anti-tumor responses in animal models, their clinical efficacy has rarely been translated into the clinic. This article attempts to present a complete picture of recent developments of DC-based therapeutic strategies addressing multiple components of tumor immunoenvironment. It also showcases certain practical intricacies in order to explore novel strategies for providing new impetus to DC-based cancer vaccination.

PMID:
22853757
DOI:
10.2217/imt.12.40
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center