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Immunotherapy. 2012 Jul;4(7):703-18. doi: 10.2217/imt.12.40.

Dendritic cell engineering for tumor immunotherapy: from biology to clinical translation.

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Division of Translational Research, Tata Memorial Centre, ACTREC, India.


Dendritic cells (DCs) are the most potent APCs, with the ability to orchestrate a repertoire of immune responses. DCs play a pivotal role in the initiation, programming and regulation of tumor-specific immune responses, as they are poised to take up, process and present tumor antigens to naive or effector T lymphocytes. Although, to an extent, DC-based immunotherapeutic strategies have successfully induced specific anti-tumor responses in animal models, their clinical efficacy has rarely been translated into the clinic. This article attempts to present a complete picture of recent developments of DC-based therapeutic strategies addressing multiple components of tumor immunoenvironment. It also showcases certain practical intricacies in order to explore novel strategies for providing new impetus to DC-based cancer vaccination.

[Indexed for MEDLINE]

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