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Transfus Med Hemother. 2012 Jun;39(3):221-223. Epub 2012 May 15.

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia.

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Institute for Transfusion Medicine, Universitätsmedizin Charité - Universitätsmedizin Berlin, Germany.



Management of patients with autoimmune hemolytic anemia (AIHA) and reticulocytopenia remains challenging.


Two patients with decompensated AIHA who were receiving immunosuppressive drugs were treated with erythropoietin (EPO). Administration of EPO increased reticulocyte counts and hemoglobin concentrations in both cases. One patient completely recovered following a short course of treatment. Hemolysis could be compensated in the second patient using only mild doses of immunosuppressive drugs in combination with EPO.


The administration of EPO should be considered in patients with therapy-refractory AIHA, particularly in the presence of reticulocytopenia.

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