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Mar Drugs. 2012 Jul;10(7):1572-81. doi: 10.3390/md10071572. Epub 2012 Jul 20.

Lochmolins A-G, new sesquiterpenoids from the soft coral Sinularia lochmodes.

Author information

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pit0424@yahoo.com.tw

Abstract

Seven new sesquiterpenoids, lochmolins A-G (1-7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1-4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

KEYWORDS:

Sinularia lochmodes; aromadendrane; germacrane; sesquiterpenes; soft coral

PMID:
22851927
PMCID:
PMC3407932
DOI:
10.3390/md10071572
[Indexed for MEDLINE]
Free PMC Article

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